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Resolve Therapeutics is an immuno-therapeutics company developing first-in-class, safe, targeted therapies for underserved autoimmune diseases.

What is Sjögren’s Syndrome?

Primary Sjögren’s syndrome is a common, systemic autoimmune disease affecting primarily women. An estimated 4 million American women suffer from the disease, which is characterized by lymphocytic infiltration of the salivary and lachrymal glands, leading to dry eyes and dry mouth. Up to 70% of patients suffering with Sjögren’s syndrome experience debilitating fatigue, which has a significant negative impact on their quality of life. Currently, there is no approved therapy for the disease.

What is Lupus?

Lupus and Sjögren’s syndrome are autoimmune diseases that arise when the patients’ immune system attacks their own body.

Lupus Symptoms

In patients with lupus, the affected organs often involve the skin, joints, kidneys, and blood vessels and can cause lupus rash, arthritis, kidney damage, or inflammation of the blood vessels. In Sjögren’s the immune system damages the salivary glands and lacrimal glands that produce saliva and tears, leading to dry eyes or dry mouth.

what is lupus
Clinical Trials

Resolve is developing a drug called RSLV-132 to treat both of these diseases and is currently conducting clinical research studies in patients with both diseases. The approach that Resolve has taken relies on fundamental research that has identified specific molecules that may be inappropriately triggering the immune system and causing the chronic inflammation seen in these diseases. By removing just these inflammatory molecules without shutting down the immune system we hope to decrease inflammation associated with lupus and Sjögren’s while not blocking the entire immune system.